Patients with uncomplicated coronary artery

Aim—To investigate whether uncomplicated chronic coronary artery disease causes changes in heart rate variability and if so, whether the heart rate variability pattern is diVerent from that described in patients with acute myocardial infarction. Methods—Heart rate variability was studied in 65 patients with angina who had no previous myocardial infarcts, no other diseases, and were on no drug that could influence the sinus node. Results were compared with 33 age matched healthy subjects. The diagnosis of coronary artery disease in angina patients was established by coronary angiography in 58, by thallium scintigraphy in six, and by exercise test only in one. Patients and controls were Holter monitored 24 hours outside hospital, and heart rate variability was calculated in the frequency domain as global power (GP: 0.01–1.00 Hz), low frequency peak (LF: 0.04–0.15 Hz), high frequency peak (HF: 0.15–0.40 Hz), LF/HF in ms, and in the time domain as SDNN (SD of normal RR intervals), SDANN (SD of all five minute mean normal RR intervals), SD (mean of all five minute SDs of mean RR intervals), rMSSD (root mean square of diVerences of successive normal RR intervals) (all in ms), and pNN50 (proportion of adjacent normal RR intervals diVering more than 50 ms from the preceding RR interval) as per cent. Results—The mean age in patients and controls was 60.4 (range 32–81) and 59.1 (32–77) years, respectively (NS), the male/female ratio, 57/65 and 24/33 (NS), and the mean time of Holter monitoring, 23.0 (18–24) and 22.8 (18–24) hours (NS). Mortality in angina patients was 0% (0/65) at one year, 0% (0/56) at two years, and 3% (1/33) at three years. Compared with healthy subjects angina patients showed a reduction in GP (p = 0.007), HF (p = 0.02), LF (p = 0.02), SD (p = 0.02), rMSSD (p = 0.01), and pNN50 (p = 0.01). No significant diVerence was found in RR, LF/HF, SDNN, or SDANN. Conclusions—Uncomplicated coronary artery disease without previous acute myocardial infarction was associated with reduced high and low frequency heart rate variability, including vagal tone. SDANN and SDNN, expressing ultra low and very low frequencies which are known to reflect prognosis after acute myocardial infarction, were less aVected. This is in agreement with the good prognosis in uncomplicated angina in this study. (Heart 2000;83:290–294)